Tissues from 41 AD cases and 41 controls were received from the Australian Brain Donor Program, New South Wales Tissue Resource Centre, which is supported by The University of Sydney, National Health and Medical Research Council of Australia, Schizophrenia Research Institute, National Institute of Alcohol Abuse and Alcoholism, and the New South Wales Department of Health (http://sydney.edu.au/medicine/pathology/trc/). Cases were excluded if there was: 1) a history of infectious disease (i.e. HIV/AIDS, hepatitis B or C, or Creutzfeldt-Jakob disease), 2) an unsatisfactory agonal status (determined from the circumstances surrounding the death), 3) a post-mortem interval >48 hours, or 4) significant head injury. In addition to case status, age, sex, ethnicity, brain weight, brain pH, post-mortem interval (PMI), tissue hemisphere, clinical cause of death, blood toxicology at time of death, smoking status, neuropathology, and liver pathology were provided for each subject (S9 Table).
