Chunk #45 — RESULTS — Hyperexcitability is reversed by chronic Li treatment of LR DG-like neurons but not of NR neurons, and Li treatment reduces cell capacitance in both LR and NR neurons
the original properties of the cells. For example, LR spikes are very narrow, and after Li treatment they become significantly broader, whereas NR spikes are broad to begin with and become broader with Li, but not significantly. While the final significant effects of Li treatment on the spike shape of LR neurons are both in the direction of reduced excitability (the fast AHP amplitude decreases and the spike broadens), the effect on the spike shape of NR neurons is in an antagonist direction; the fast AHP amplitude decreases, which reduces excitability, but the threshold for evoking an action potential is less depolarized, and this has the effect of increasing cell excitability, resulting in a similar number of hyperexcitable neurons after Li treatment.
