We subsequently investigated whether genes near sentinel variants were enriched for certain functional pathways. We included genes within ±0.5Mb of the 390 sentinel variants with a significant eQTL in either tissue identified above (aorta and tibial artery). We identified 2,013 genes near all 390 sentinel variants (Online Methods) and tested for functional annotation enrichment. Using DAVID 6.834,35, 1,480 had annotations, producing 26 significant annotation terms (Benjamini-Hochberg P<0.05, Supplementary Table 10), without a clear functional pathway emerging.
