Fig. 3) and AAs (λ = 1.02; Supplementary Fig. 2).Table 1Meta-analysis of rs115455482 and rs74722579 in European American (EA) and African American (AA) long-term cannabis users.PopCohortaHallucination control no.Hallucination case no.SNPbAlleleMAFcEffect β (SE)dPCaseControlEAYale-Penn 1104151rs115455482T0.1670.0400.13 (0.03)4.93 × 10−9rs74722579C0.1770.0480.12 (0.03)1.66 × 10−8Yale-Penn 278540rs115455482T0.0880.0310.08 (0.02)4.08 × 10−3rs74722579C0.0880.0360.07 (0.02)3.15 × 10−2COGAe2118256rs115455482T0.0590.0580.05 (0.21)8.08 × 10−1rs74722579C0.0630.0640.02 (0.20)9.34 × 10−1Meta-analysis3944347rs115455482T0.111.32 × 10−10rs74722579C0.102.60 × 10−9AAYale-Penn 11461149rs115455482T0.0170.0070.10 (0.06)9.97 × 10−2rs74722579C0.0740.0480.05 (0.02)5.27 × 10−2Yale-Penn 268771rs115455482T0.0150.0050.02 (0.01)8.65 × 10−1rs74722579C----COGA1114142rs115455482T0.0110.013−0.12 (0.61)8.40 × 10−1rs74722579C0.1030.0880.19 (0.26)4.50 × 10−1Meta-analysis3262362rs115455482T0.061.37 × 10−1rs74722579C0.054.58 × 10−2EA + AAMeta-analysis7206709rs115455482T0.115.66 × 10−11rs74722579C0.081.60 × 10−9aIllumina microarray HumanOmni1-Quad v1.0 and HumanCore Exome array were used to genotype samples for Yale-Penn 1 and 2, respectivelybRs115455482 is highly linked with rs74722579 in EA (r2 = 0.95) but not in AAs (r2 < 0.2). rs115455482 is a common variant in EAs but a rare variant in AAs, meanwhile rs74722579 is a common variant both in EAs and AAscMinor allele frequencydEffect β and SE based on likelihood ratio test by using the software Genome-wide Efficient Mixed Model Association (GEMMA)eCOGA: Collaborative Study on the Genetics of AlcoholismNote: The two variants are imputed with imputation score > 0.8 among all cohorts. Cannabis users who use cannabis ≥1 year and ≥100 times are defined as long-term cannabis users. Results for
