Chunk #12 — 2. Materials and Methods — 2.2. Image acquisition, processing, and analysis

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Lower Prefrontal and Hippocampal Volume and Diffusion Tensor Imaging Differences Reflect Structural and Functional Abnormalities in Abstinent Individuals with Alcohol Use Disorder.

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In addition, we used a multi-atlas hippocampus segmentation algorithm (Heckemann et al., 2006) implemented in-house to measure hippocampal volume (HV) for cross-validation purposes. The automated hippocampus segmentations on all 60 participants were visually inspected for accuracy using the ITK-SNAP (www.itksnap.org) software (Yushkevich et al., 2006). An example of the automatically segmented hippocampus displayed using ITK-SNAP is shown in Figure 1a in the results section. Quantitative accuracy assessments using leave-one-out cross-validation yielded an average Dice index of 0.86 between manual and automatic segmentations.