effect may partially explain some of the paradoxical excitatory actions of alcohol, which are perceived as positive by some individuals and could contribute to the development of alcoholism. The only other kainate receptor gene that has been studied as a candidate for alcohol-related disorders is GRIK3, which encodes the GluR7 subunit. Preuss et al. (2006) found an association in a German case-control sample of a functional Ser310Ala polymorphism with a history of delirium tremens. That finding, however, was not replicated in Polish family-based or case-control samples, in which delirium tremens and other alcohol-related phenotypes, including AD, were examined (Samochowiec et al. 2006).
