In the EA family sample, 6 of the 11 markers, including rs1133503 from the genome scan,24 showed at least a nominally significant association with CIP (Table 3). These 6 markers and 3 others were also significant in the AA family sample. The patterns of association were identical in the 2 population groups for all 9 markers (which represent all markers tested in the promoter and coding regions), evidenced by increased significance in the total sample of families. The strongest evidence for association in either population (AA, P<.001) and in the total sample (P<.001) was observed with rs6937479, which is located in the putative promoter region. The association of MANEA SNPs with CD was much weaker. In the EA families, nominally significant results were obtained with rs9374586 (P = .01), rs1133503 (P = .04), and rs9387522 (P = .03). Although no significant associations were obtained in the AA families, trends were evident in that population for several markers. Eight markers (rs9400554, rs9320497, rs6937479, rs9374586, rs9400893, rs1133503, rs9387522, and rs9387605) were nominally associated with CD in the total group of families (.007≤P≤.03).
