SZ.18 Moreover, the DISC1 locus has not reached genome-wide significance in large-scale meta-analyses of linkage studies of SZ,19 nor have its common variants in large-scale genome-wide association studies of SZ, BD or rMDD.20, 21, 22 A recent exon-based study that sequenced 2.7 kb of DISC1 in 727 cases of SZ and 733 controls found 32 rare alleles (minor allele frequency (MAF)<0.01) in SZ cases and 40 in European controls with no evidence for a significantly increased burden of likely pathogenic variants.23 DISC1, however, continues to feature strongly in attempts to assess genome-wide association results in terms of networks24 or in combination with known biological function.25, 26, 27
