Monoamines including serotonin (5-hydroxytryptamine, 5-HT), norepinephrine (NE), and dopamine (DA) are modulators of emotionality, cognition, and reward. Therefore, it is unsurprising that genes regulating monoamines such as catechol-O-methylrans-ferase (COMT) and the serotonin transporter (SLC6A4) have been implicated in vulnerability to several psychiatric diseases, including addictions.
