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Chunk #31 — Discussion

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Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control.
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The twin correlations in the current study also suggest potential sex differences in how behavioral control and negative emotionality confer risk for psychopathology. In particular, there was a notable difference in DZ correlations involving MDD for men and women, but MZ correlations were similar for men and women. Future research may benefit from including opposite-sex twin pairs to investigate whether quantitative or qualitative sex differences confer risk for psychopathology via behavioral control and negative emotionality (Neale & Maes, 1999; Neale et al. 2006).