We then tested the 7 SNPs that showed definite or nominal significance in the NETT-NAS case-control population, and the results are provided in Table 2. These results further confirmed the association of two SNPs at the CHRNA3/5 locus with COPD (p = 2.5×10−3, OR = 1.43, combined p value: 1.48×10−10 for rs8034191 and p = 0.017, OR = 1.32, combined p value 5.74×10−10 for rs1051730). Two SNPs (rs1828591 and rs13118928) at the HHIP locus on chromosome 4 also showed consistent replication across the three cohorts, but the combined p values did not reach genome-wide significance (1.47×10−7 and 1.67×10−7 respectively).
