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Chunk #35 — RESULTS — Association with Alcohol Dependence

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Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.
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Table III). The odds ratio (OR) for the G allele is 1.24 [95% CI: 1.06 – 1.45], with an increased OR of 1.32 [95% CI: 1.02 – 1.71] when tested for a full recessive model (P = 0.036), suggesting a significant recessive mode of genetic influence on the development of alcoholism by the HTR7 risk allele. Concordantly, the mean theta ERO value for the G/G homozygotes is 3.51 ± 1.11 μV, revealing a near significant oscillatory deficit (P = 0.084) relative to the combined mean for the other two genotype classes (3.62 ± 1.12 μV).