We detected no significant associations for European American cases, using a Bonferroni genome-wide significance level of p<5×10−8, which is a widely used and highly conservative method used to address the problem of multiple tests in GWA studies. We performed follow-up genotyping with a number of the SNPs that were shown to associate with a lower significance p-value of p<10−5 in a larger cohort of 229 European American cases. We were unable to replicate any of these associations, leading us to conclude that there are no common variants with large effect with respect to susceptibility to FSGS. Because no common variants were found, this confirmed our belief that stratification did not create false positive associations.
