We selected a subset of 16 genetically uncorrelated traits by ranking all traits according to the number of PolyFun + SuSiE PIP>0.95 SNPs and greedily selecting top-ranked traits such that no selected trait has |rg|>0.2 with a previously selected trait, excluding traits having either (1) hg2 estimates <0.05 in either the PolyFun dataset (N=337K) or in the PolyLoc dataset (N=122K) (see hg2 estimation description below); or (2) traits with an effective sample size <100K in the N=337K dataset (using 4/(1/#cases + 1/#controls) for binary traits).
