tumours, presenting similar histological characteristics to those observed in the respective primary tumours, even upon secondary transplantation of 500 cells (Supplementary Fig. 6b–e and Supplementary Table 3). In agreement with the similarities between p53KDiNPCs and WTiNPCs, p53KDiNPCs did not lead to secondary tumour formation upon serial transplantation regardless of the number of cells injected (Supplementary Table 3).
