The main finding from this study is that among nicotine-dependent boys, faster nicotine metabolism predicted higher mean puff volume (a predictor of cessation-treatment failure) but lower puff duration and fewer puffs. These results are in partial agreement with those of a recent study of adult smokers [9]. Metabolic differences across sex and ethnicity found in this adolescent sample have been described elsewhere [18, 20] and are consistent with those demonstrated among adult smokers [19, 27].
