Because of the low allele frequency of rs4952, this association was modeled as homozygous for the common allele (CC) versus all other genotypes (CT and TT). Results from our analyses of rs4952, controlling for rs13273442 by including it as a covariate in the model, are listed in Table 3. The power is decreased for this analysis compared to our primary analysis of rs13273442 due to the low frequency of the T allele of rs4952. Nonetheless, in both ancestry groups the summary estimate of effect is strongly protective (OR=0.75 for European Americans, OR=0.59 for African Americans), though the confidence intervals are wide. Meta-analysis across the ancestral populations yields a statistically significant odds ratio between the common CC genotype and carriers of the T allele (OR=0.72, p=0.02).
