We previously reported that ZBTB16 repressed Nuclear factor (NF)-κB-mediated gene induction by stabilising the nonproductive NF-κB1 (p50) transcription factor on gene promoters21,22. Considering the role of NF-κΒ in the expression of IL-1β and Gasdermin D (GSDMD), we tested the physiological consequence of ZBTB16 for inflammasome activity by challenging WT and Zbtb16 mutant mice with a variety of inflammasome activators.
