Accordingly, with growing attention focused on the incorporation of genetic information into prevention science, it is worth pausing to think critically about why we are investing considerable time and effort into genetically informative prevention studies, and where this line of research is likely to lead. What are the opportunities and challenges associated with this line of research? In what areas of genetically-informed prevention science are we doing well, and in what areas do we fall short? And, importantly, what implications do these studies have for the practice of prevention/intervention in the future? In this commentary, I address these questions. I certainly do not pretend to have all the answers; rather, I hope that this commentary will stimulate conversation about the future role of genetic information in prevention science.