effects of ibuprofen involved PPARγ activation and its ability to inhibit RhoA activation (Dill et al., 2010). This effect may be mediated by SHP-2 (Src homology region 2-containing protein tyrosine phosphatase-2), which is involved in the PPARγ-dependent inhibition of RhoA (Wakino et al., 2004). However, the potential role of SHP-2 in PPAR-mediated neurite outgrowth has not yet been studied in the CNS. Like their ability to promote neuronal survival, these studies show that PPAR activation can positively affect axon regeneration.
