There are fundamental issues relating to the computational prediction of human gene regulation. Future research will include both prediction models on gene regulation and analysis tools for interpreting prediction results. As more experimental data accumulates related to the nature of TF-DNA interactions, we plan to further develop our predictions on tissue-specific TF interactions. We also plan to extend our work on CRM detection by relating regulatory elements with temporal (e.g., development) and spatial (e.g., cell types) attributes. As new predictions on tissue-specific gene regulation accumulate, the TiGER database will need to be further expanded and modified. We will update the content of the database on a regular basis. We also plan to develop tools relating TiGER data to other available gene expression and regulation data for integrative analysis.
