syndrome) are associated with ADHD 27, 28. Evidence for an increase in comorbid conditions in female individuals with ADHD, when compared with affected male individuals, would imply a more severe syndromal phenotypic presentation of ADHD in a higher proportion of female individuals. Such more complex presentations are arguably more likely to be linked to deleterious rare mutations. A higher rate of these comorbidities in female individuals would also be consistent with clinical heterogeneity, which may pertain to the observed prevalence differences.
