With regard to alcohol intake during the first 5 days of the alcohol reaccess period, there was a significant effect of treatment F (3, 42) = 8.9, p<0.001, and day F (4, 168) = 10.1, p<0.001, but no treatment X day interaction. Dunnett’s multiple comparisons against a single mean (VEH) revealed that VAR, in doses of 1.0, and 2.0 mg/kg BW, each reduced alcohol intake (p<0.001, and p<0.05, respectively) (Fig. 4). Dunnett’s multiple comparisons for each dose against a single mean (VEH) within day, revealed that the lowest dose of VAR (0.5 mg/kg BW) did not reduce alcohol intake on any of the 5 days of drug treatment. A higher dose of VAR (1.0 mg/kg BW) reduced alcohol intake on all 5 days of treatment (days 1, 2, and 4, p<0.05; days 3 and 5, p<0.01), and the highest dose of VAR (2.0 mg/kg BW), reduced alcohol intake on days 4 and 5 of treatment (p<0.01, and p<0.05, respectively).
