Chunk #20 — MATERIALS AND METHODS — Genotyping Quality Control

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Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes.

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For OPRM1 genotyping, approximately the first 100 subjects were genotyped in both our lab and that of David Goldman (Neurogenetics Lab at NIAAA) with 100% agreement. Four samples each representing asn40 homozygotes as well as asp40asn hetero and asp40asp homozygotes, with identical identification in both labs were used as “positive controls” for all subsequent Taqman assays.