to our significant haplotype; rs4680 forms part of the haplotype for which we observed the most interesting results also. Our observations in the EA population were consistent with the study by Stein et al. (Stein et al., 2005) who found an association of COMT variants with the personality traits of neuroticism and extraversion. However, there is no haplotype that has been consistently studied and shown to be associated to these phenotypes. It is clearly the case that Val108/158Met is not the only important functional variant at this locus.
