a coherent cluster in the non-demented state or LOAD, respectively. Thus, new modules are created in LOAD while in other cases a portion of the network is completely disrupted. The statistical significance of the MDC metrics was computed through the false discovery rate (FDR) procedure as described in Extended Experimental Procedures. Based on 10% FDR, 54% of all modules showed GOC while 4.5% of modules exhibited LOC. The structure of the remaining 41.5% of the modules were found to be conserved across the LOAD and non-demented states by this MDC measure. We note a negligible overlap of only 6% between signatures of differential connectivity and standard differential gene expression in LOAD brains, implying that the observed disruption in co-regulation of genes reflects a previously untapped marker of LOAD neuropathology.
