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Chunk #26 — Transcription Factors in D1 vs. D2 MSNs

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The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons.
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Robinson, 2004) and chronic administration of amphetamine is reported to selectively induce c-Fos in D2+ MSNs (Mattson et al., 2007). These different results could be a reflection of the experimental procedures used (in situ hybridization vs. GFP reporter mice) or even be due to the animal species used as the latter experiments used rats.