The estimate of the SNP-based heritability of depression within our meta-analysis was 0.089 (0.003) on the liability scale using LDSC regression 10. Heritability was then partitioned by calculating the proportion of heritability assigned to 24 functional categories divided by the proportion of variants in that category. This partitioning showed significant enrichment within conserved, intronic and H3K4me1 regions of the genome for the heritable component of depression (Pcorrected < 0.05), see Supplementary Figure 7 and Supplementary Table 5. However, the estimates of enrichment for intronic (1.16×, s.e. = 0.05) and H3K4me1 (1.41×, s.e. = 0.13) regions were much smaller compared to the conserved regions (17.49×, s.e. = 1.68) of the genome.
