of SNPs on 7p14, 8p11, 10q23, 15q25, and 19q13, on lung cancer risk, that also utilizes circulating cotinine measures as proxies for recent smoking behavior. The study further benefits from several important characteristics, including the prospective study design and detailed information on tobacco exposure. The study was however not adequately powered to detect the small risk effects expected of some of the studied SNPs (OR ranging from 1.05 to 1.12). It would also have been desirable to measure alternative nicotine metabolites to better describe the opposing associations of SNPs on 19q13.
