For Parkinson’s disease, we performed an inverse variance-weighted meta-analysis 90 using summary statistics from Nalls et al. 19 (9,581 cases, 33,245 controls) and summary statistics from 23andMe (12,657 cases, 941,588 controls). We found a very high genetic correlation (rg) 20 between results from these cohorts (rg=0.87, s.e=0.068) with little evidence of sample overlap (LDSC bivariate intercept=0.0288, s.e=0.0066). The P-values from the meta-analysis strongly deviated from the expected (Figure S22) but was consistent with polygenicity (LDSC intercept=1.0048, s.e=0.008) rather than uncontrolled inflation 20.
