ALE revealed four significant clusters of convergent macro- and microstructural WM alterations in AUD patients compared to healthy controls, which are shown in Fig. 2. The largest cluster (C1) comprises parts of the midbody of the corpus callosum and the fornix in both hemispheres. The other clusters are mainly located in the right hemisphere and C2 also covers the posterior body of the corpus callosum with extension to the posterior cingulum bundle. The third cluster (C3) can be assigned to the right posterior limb of the internal capsule and the smallest and last cluster (C4) shows convergence in the genu of the corpus callosum with extension to the anterior cingulum bundle. The cluster sizes, peak-coordinates, and associated ALE values as well as the centers of mass are reported in Table 2.Table 2ALE clusters significant after cluster-level FWE correction for multiple comparisons.Peak voxel coordinates (MNI)Cluster #Anatomical labelaxyzALE (*10−2)bCluster size (mm³)Center of mass (x, y, z)Contributing studies (%)cFail-Safe N(%)c1I Fornix0−8162.842 200−1, −4.4, 16.98 (44.4)12 (66.6)I Corpus Callosum06222.24L Fornix−4−16121.78L Fornix−6−20141.752R Corpus Callosum6−18282.231 77610.1, −21, 29.47 (38.8)51 (283.3)R Cingulum10−24262.19R Corpus Callosum20−24361.533R Internal Capsule16−12−82.101 06418.8,
