Beyond TF binding profiles, JASPAR provides several complementary features to the community to compare, analyse, and interpret genomic data in the context of transcriptional regulation of gene expression. Users can visualise the TF binding profiles' similarity in the CORE and UNVALIDATED collections through a radial tree. We updated the RSAT matrix-clustering tool (37) into a faster and expanded stand-alone version (https://github.com/jaimicore/matrix-clustering_stand-alone). We applied the tool to the PFMs stored in JASPAR to provide hierarchical clustering of the profiles in every taxon. To remove redundancy due to similar profiles, we computed familial binding profiles, which summarise similar profiles with a single PFM, by relying on hierarchical clustering (38). We followed the same methodology as introduced in the previous JASPAR release (9) to construct 408 familial binding profiles (155 for vertebrates, 52 for plants, 62 for fungi, 44 for nematodes, 76 for insects and 19 for urochordates). We provide all hierarchical clusters and familial binding profile summaries at https://jaspar.elixir.no/matrix-clusters.
