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Chunk #43 — ONLINE METHODS — Case-control studies

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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.
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We know from the methods above that the scale of measurement of a quantitative trait is not important, as it can be dropped from the equations. We therefore extend these methods to be applied to the case-control study design, assuming that the disease liabilities (L) of all the individuals are known, and model the effects of multiple SNPs. (24)L=Xb+e