A total of 746,626 autosomal SNPs that passed quality control were analyzed in 816 community nondiabetic and 899 T2DM-ESRD subjects (cohorts 1 and 2) separately for association with BMI. The inflation factors were 1.013 and 1.011 for cohorts 1 and 2, respectively before genomic control. The association results combined using an inverse variance weighted meta-analysis and the respective quantile–quantile plot (inflation factor = 1.005 after genomic control) are shown in Supplementary Figures S1 and S2 online, respectively. The inflation factor for heterogeneity P values between the two GWAS was 1.002, suggests in general there was no significant heterogeneity in the associations between the two cohorts (Supplementary Figures S3 online). A total of 70 SNPs showed nominal association at P ≤ 1 × 10−4 in the meta-analysis. The most significant SNP was rs7791504 located in an intergenic region on chromosome 7 (P = 5.47 × 10−9).
