SCZ, BiP and MDD are genetically correlated (rg = 0.34–0.70) suggesting pleiotropic effects of variants across these three disorders. Despite the genetic correlations consistently observed among these conditions, patterns of associations with SCZ PRS differed markedly from those observed for BiP and MDD PRS (Supplemental Fig. 4). Whereas influences of SCZ PRS were observed only for males aged 16–20 (Fig. 2), both BiP PRS and MDD PRS had influences in both males and females, with BiP effects appearing later in females, and MDD effects manifesting in females after age 24 (Figs. 4–5). Additionally, SCZ PRS effects are more widespread throughout the brain, impacting frontal, central, posterior, and both interhemispheric and intrahemispheric electrode pairs, whereas effects of BiP and MDD PRS were largely interhemispheric and central-posterior. While some of these observed effects are shared across all three conditions25, the similarities and distinctions are in line with what is known regarding the shared and unique genetic and neural contributions to SCZ, BiP, and MDD.
