Since the SPOT prioritization results are not intended to predict causal variants, we recommend that the statistical significance of GWAS results be evaluated based on genotype–phenotype correlation data alone and be corrected for genome-wide multiple testing in accordance with current standards (1). In particular, this practice will help to guard against bias from reports of positive association in the literature, as well a bias from the biological priorities of the investigators which may lead to a misinterpretation of the results of the GWAS.
