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Chunk #0 — Introduction

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A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders.
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Immunological factors are increasingly recognized as etiologically important in a range of neuropsychiatric disorders, such as autism spectrum disorder,1 schizophrenia,2 or bipolar disorder.3 The potential link between immunological factors and psychiatric symptoms has been much debated in obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD), due to the still controversial link between group A streptococcus infections and the abrupt onset of these psychiatric symptoms in a small group of children.4, 5