present results demonstrating offline stimulation effects for longer than 50 minutes, we speculate that the external manipulation of theta-gamma PAC and theta phase synchronization that improved behavior may be due to neuroplastic changes in functional connectivity. That is, by noninvasively intervening in the temporal synchronization patterns of large-scale human brain activity, the results suggest it may be possible to enhance the postsynaptic effect of spikes from one area on another, thereby improving neural communication associated with the control and storage of information in working memory. However, while the present work hints at this conclusion, further research is required to more thoroughly explore the hypothesis that theta-tuned frontotemporal HD-tACS is capable of eliciting neuroplastic modifications in functional connectivity with direct and lasting behavioral consequences.
