In this paper, we have examined the conceptualization, development, and implementation of a multilevel approach to CBPR, which integrated CBPR principles and practices and features of randomized, multicommunity trials. This was an attempt to address some of the shortcomings of conventional CBPR approaches such as the focus on a single community and the lack of focus on policy change. At the same time, it was an attempt to address some of the shortcomings of community trials focused on policy, such as lack of stakeholder involvement in framing the research question and moderate to minimal engagement of stakeholders in implementing the project and in interpreting and disseminating results.