The over-arching purpose of the PGC is to conduct high-quality GWAS mega-analyses in order to foster rapid progress in what has been a complex and uncertain scientific area. These results are meant to inform research into ADHD, autism, bipolar disorder, major depressive disorder, and schizophrenia along with searches for genetic loci that predispose to more than one disorder. The initial iteration of the PGC had four scientific aims, which were designed to facilitate the over-arching scientific goal of attempting to identify secure associations of comprehensive assessment of common genetic variation with five critically important psychiatric diseases.