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Chunk #15 — MATERIALS AND METHODS — Study samples and measures of alcohol use — FINRISK study population

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μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption.
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In the FINRISK 2007 Study, alcohol consumption was analyzed with three different methods: the Alcohol Use Disorders Identification Test (AUDIT) questionnaire, Timeline Follow-back (TLFB) and quantity-frequency (QF) questions. AUDIT has been developed to screen for heavy drinking (Saunders et al., 1993) and the instrument has 10 structured questions with the maximum score of 40. Heavy drinking is generally defined as having ≥8 points in the questionnaire (Reinert and Allen, 2007). According to this definition, 541 (23.0%) of the FINRISK study population would be classified as heavy drinkers. In this study, the AUD score was used as a continuous score.