Chunk #76 — ONLINE METHODS: — Replication of the general-risk-tolerance lead SNPs and maxFDR calculation

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

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To calculate the “maxFDR,” an upper bound on the false discovery rate (FDR) for a GWAS, we used the MTAG software16 and followed the methodology described in section 1.4.3 of Turley et al.’s Supplementary Information16. The maxFDR is defined as the maximum theoretical FDR over a range of possible fractions of null SNPs (πnull).