Up to this point, our analysis has focused on annotated regions (genes, promoters, and enhancers). However, in addition to the canonical expression differences in protein-coding genes, we also found differences in unannotated noncoding and intergenic regions (fig. S30). In particular, testes and lung have the largest extent of transcription overall (the most genes transcribed) for protein-coding genes (Fig. 3D). However, when we shift to unannotated regions, the ordering changes: Brain tissues, such as the cortex and CB, now have a greater extent of transcription than any other tissue.
