We report convergence of common and rare variants in a set of 18 genes defined by location of credible variants. Thirteen of the genes were hit by rPTVs, and eight had a higher load in cases compared to controls, and thus, the signal was not driven by a few genes but by several genes with an increased burden of rPTVs. Of particular note, SORCS3 seems to be implicated in ADHD by both common and rare variants. Common variants in SORCS3 show strong pleiotropic effects across several major psychiatric disorders50, but to our knowledge, rare variant analyses have not implicated SORCS3 in psychiatric disorders before. Our results add to the emerging picture of overlap between genes and pathways affected by common and rare variants in psychiatric disorders54,60–62.
