UKB REX item. The relatively low REX variance explained by MVP PRS in the UK Biobank cohort is consistent with the limited SNP heritability estimates for MVP and UKB REX phenotypes, 6.7% and 4.3% respectively. Since the MVP trans-ancestry meta-analysis is mainly driven by the EA sample (N=146,660) with a small contribution by AAs (N=19,983), we also checked the replication of the trans-ancestry meta-analysis in the UKB sample, which includes only individuals of European descent. Among the six variants that reached genome-wide significance in the trans-ancestry meta-analysis (Table S5), four were replicated in the UKB cohort: TCF4 rs12458015 (MVP p=9.6 ×10−11; UKB p=9.91×10−5), CRHR1 rs1724409 (MVP p=3.55×10−11; UKB p=2.42 ×10−3), HSD17B11 rs12649023 (MVP p=1.32×10−8; UKB p=8.78 ×10−3), and CAMVK rs2681780 (MVP p=8.82×10−12; UKB p=2.42 ×10−3).
