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Chunk #3 — INTRODUCTION

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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
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We found that a polygenic score derived from our results explains around 11% of EA variance. We also report additional GWAS of three phenotypes that are highly genetically correlated with EA: cognitive (test) performance (N = 257,841), self-reported math ability (N = 564,698), and hardest math class completed (N = 430,445). We identify 225, 618, and 365 lead SNPs, respectively. When we jointly analyze all four phenotypes using a recently developed method11, we found that the explanatory power of polygenic scores based on the resulting summary statistics increases, to 12% for EA and 7–10% for cognitive performance.