superfamily gene, CNTNAP2, were also identified in three individuals with schizophrenia and epilepsy. Allelic variants of the CNTNAP2 gene have been found to be associated with autism in three recent studies. Chromosomal rearrangements of both the CNTNAP2 and IMMP2L genes have been reported in patients with Tourette syndrome, and the IMMP2L gene is present within the 7q22 AUTS1 locus identified by several autism association studies. Similarly, chromosomal rearrangements disrupting the AUTS2 gene have been reported in five autism patients. Finally, a rare copy number variant in a schizophrenic patient was found to overlap with the glutamatergic receptor GRM7. We observed an ADHD proband with a CNV in GRM7 who also presented with anxiety. The extinction of conditioned fear, blocked with downregulation of GRM7, suggests that some of these CNVs may potentially explain certain comorbidities frequently associated with ADHD.50, 51
