Two pathways in EAs with several overlapping genes were significantly associated with FTND (false discovery rate <.05): endothelial nitric oxide synthase (eNOS) and adenosine monophosphate-activated protein kinase (AMPK) signaling. Both pathways contain the genes CHRNA5 and CHRNA3, each of which had an SNP with a gene-wide independent test-corrected p value <.05. No pathways were significant in AAs.
