Twelve of the 21 previously reported HR-associated SNVs (12) covered on the Exome Chip explain 1.14% of RR-interval variance (P = 3.96 × 10−10) within the 1958 Birth Cohort study (see Materials and Methods). The added contribution of the lead SNVs at our five unreported novel loci, combined with the 12 previously reported SNVs, increases the variance explained to 1.28% overall (P = 9.17 × 10−11).
