studies. Weakness withdrawal symptoms were also found in lab studies 13, 14 and in a clinical study of adolescents, especially males. 20 While fatigue was not found during cannabis withdrawal among cannabis users in their home environments, 17 the other studies in conjunction with the present findings indicate that these symptoms merit further investigation. Irritability and anxiety may receive greater clinical consensus as regular features of cannabis withdrawal because they are subjectively and clinically striking compared to fatigue and related symptoms. Varying emergence of weakness and depression/anxiety symptoms as part of cannabis withdrawal may also relate to varying levels of Δ9-THC in cannabis and varying levels of other cannabinoids that, while weaker than Δ9-THC, may interact with Δ9-THC to alter its effects. 42
